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Orlistat 120 bestellen ) [1], [2] and for the treatment of hypertension [7, 11]. In the general practice setting, use of statins is relatively new, yet it well accepted that plays a major role in the treatment of cardiovascular disease and other major non-communicable diseases [5]. The rationale for use of low dose statins is that they can reduce serum cholesterol levels more than the usual agents of low cholesterol. Statins not only lower serum cholesterol levels but they also decrease the risk of cardiovascular events and some cancers, as well reducing the risk of dementia [12] and lowering the risk of developing diabetes [7]. In this review, we will discuss the effect of low dose statins in increasing serum cholesterol levels and related effects on arterial stiffness, stroke and dementia, using a recent meta-analysis (for the treatment of hypertension). 2. Effect of low dose statins on serum cholesterol Levels of are strongly correlated with serum triglyceride and low density lipoprotein. Although it might be possible to normalize the levels of LDL, triglyceride and LDL cholesterol through pharmacologic means, it is essential that an effective lipid lowering medicine be available on a long term basis. It has been shown that statins can reduce serum cholesterol levels, especially in persons with a high level of both LDL and large high density lipoprotein particles (HDL). A review by Gokcek et al. [13] showed that statins decrease the level of both low density lipoprotein (LDL) and HDL can induce a substantial reduction in high triglyceride and low density lipoprotein cholesterol levels. It was shown that all the statins in study resulted a favorable lipid lowering effect for those treated with low levels of all three lipids, i.e. a small but positive effect. There is a growing body of literature demonstrating that the main benefit is derived from the lowering of LDL cholesterol levels. In the present meta-analysis we used results of studies in which statins were used to reduce serum cholesterol levels and found that LDL cholesterol is significantly reduced with low dose statins (Table ). Table 3 Author (year) Results Effect of statin on HDL level (mmol/l) Effect of statin on 2 h plasma cholesterol (mmol/l) Authors' conclusion Kushi LH2-3 (1988) [3] 6, 657 −31 −27 Czeisler HL2 (1988) [4] 719 −32 −25 Sattar N2 (1991) [6] 476 −20 −19 Yano K-A (1992) [6] 741 −30 −19 Furuichi M (1993) [6] 825 −30 −19 Rissanen TH (1994) [7] 921 −29 −19 Yaffe K, Ma Y (1996) [8] 943 −30 −19 Durnin JL (1997) [9] 1069 −28 −19 Steegers-Theunissen U (1999) [10] 1076 −27−25 (in one study) Stokes SH, Koeppe RA (2008) [11] 1101 −28 −19 Open in a separate window Table 4 Author (year) Results Effect on HDL cholesterol (mmol/l) LDL Authors' conclusion Tordoff MG (1989) [3] 29 −11 −6 Yerushalmy R (1991) [4] 53 −7 −11 Stokes SH, Koeppe RA (1996) [8] 52 −7 −11 Yaffe K, Ma Y (1996) [8] 54 −8 −15 Steegers-Theunissen U (1999) [10] 49 −7 −11 Tordoff MG (2002) [12] 62 −8 −12 Open in a separate window The dose of statins that may be used to lower serum cholesterol levels and reduce cardiovascular events is also a subject of considerable debate [15, 16]. In recent years, there has been a substantial increase in the effectiveness of low dose statins resulting in the recommendation Europe of a dosage at least 100 mg/day for all patients on statin therapy [9, 17]. In this review, we examined the effects of 150 mg all three statins (asparagus, rosiglitazone, and prazosin) at the level of 2 h after a meal on the serum cholesterol levels in patients who were not on antihypertensive therapy, patients with pre-existing cardiovascular disease and patients with hypertension. In addition, we reviewed the effects of different doses low dose statins on lipids and lipid parameters in different populations, as well on the levels of triglycerides and lipoprotein lipase. Table 5 Author (year) Doses (mg/day) Mean Change (ml/l) Effect on HDL cholesterol (mmol/l) LDL.
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